Opiates are labeled “natural”, because nature creates the active ingredient molecules. Common opiates include opium, morphine and codeine, both made directly from poppy plants. An opioid is a substance (molecule) that is synthetic or partly synthetic. This means the active ingredients are created chemically.
Source: https://recoverycentersofamerica.com/blogs/opiate-vs-opioid-do-you-know-the-difference/#:~:text=Opiates%20are%20labeled%20%E2%80%9Cnatural%E2%80%9D%2C,active%20ingredients%20are%20created%20chemically.